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KMID : 0848120200450010025
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International Journal of Oral Biology
2020 Volume.45 No. 1 p.25 ~ p.31
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Implications of specific gene expression patterns in enamel knot in tooth development
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Kim Tae-Young
Neupane Sanjiv
Aryal Yam Prasad
Lee Eui-Seon
Kim Ji-Youn
Suh Jo-Young
Lee Young-Kyun
Sohn Wern-Joo
An Seo-Young
Ha Jung-Hong
An Chang-Hyeon
Kim Jae-Young
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Abstract
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Enamel knot (EK)?a signaling center?refers to a transient morphological structure comprising epithelial tissue. EK is believed to regulate tooth development in early organogenesis without its own cellular alterations, including proliferation and differentiation. EKs show a very simple but conserved structure and share functions with teeth of recently evolved vertebrates, suggesting conserved signaling in certain organs, such as functional teeth, through the course of evolution. In this study, we examined the expression patterns of key EK-specific genes including Dusp26 , Fat4, Meis2, Sln , and Zpld1 during mice embryogenesis. Expression patterns of these genes may reveal putative differentiation mechanisms underlying tooth morphogenesis.
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KEYWORD
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Mice, Molar, Genes, Epithelium, Embryonic development
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